You can wipe it down! This is the main reason we love it - we're all about reducing laundry. However, in the early days, babies hate being cold and they hate being changed, so putting a swaddle or baby blanket down makes things easier as you can quickly toss the swaddle in the laundry.
You probably won't change your kiddo on a changing table for at least 8 months—when they start showing interest in rolling over and your changes become more like wrestling matches. That being said, this is a moment. Once my kids rolled over, I invested in THIS for the floor of their bedrooms and changed them here. Note: their rooms have thick carpets so this was safe for them; if you don't have a thick rug, you'll want something thicker and/or with foam support.